PackGene provides preclinical grade plasmids that come with extensive and rigorous quality specifications and analysis, catering to all of your preclinical project requirements. They are perfectly suited for in vivo animal studies from mice to non-human primates, and are ideal for research use in gene therapy, cell therapy, and vaccine development. Quantities are available starting from 10 mg and beyond.
Comprehensive quality control of supercoil content and endotoxin levels
Animal- free production is available
Quantitative impurity analysis
Guaranteed quantity of mg to gram with material archiving option
| PackGene plasmid process | Preclinical |
| Clone screening | √ |
| Growth condition optimization | √ |
| High density fermentation | √ |
| Alkaline lysis | √ |
| Chromatographic purification | √ |
| Antibiotics free | √ |
| Consistent manufacturing process | √ |
| Instrument calibration/validation | Calibration |
| COA & CoC | COA |
| TSE/BSE | O |
| Antibiotics Free Production | √ |
| Animal Free Production* | O |
| Material Archiving | Plasmid archived, additional charges for bacteria |
| Test | Methods |
| Appearance | Visual inspection |
| A260:280 | Ultraviolet-visible spectrophotometry (A260/A280) |
| Homogeneity | HPLC |
| Restriction Analysis | Agarose gel |
| Residual RNA | SYBRGold |
| Residual E. coli DNA | qPCR |
| Endotoxin | LAL |
| Bioburden Testing | Direct inoculation |
| Sequencing | Sanger |
| Residual Host Protein | HCP ELISA |
| Mycoplasma Contamination | qPCR |
| pH | Potentiometry |
| Residual Kanamycin | ELISA |
| Sterility | |
| Osmolality |
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